Реферат: Cyclodextrins (CDs) are unique macromolecules with a hydrophilic outer surface and a hydrophobic inner cavity, which can include a wide range of guest molecules, forming various host-guest inclusion complexes [1-2]. In formed complex CD protects the "guest" molecule from damage by various reactive molecules. Due to this property, CDs are widely used in pharmaceuticals, the food industry, as fixed phases in chromatography, etc. The solid phase of cyclodextrins is almost always a hydrate, and therefore, the process of formation of inclusion complexes is the process of complete or partial substitution of water molecules in CDs hydrates by guest molecules. Therefore, quantitative thermodynamic characteristics of dehydration processes are very relevant for obtaining various CD-inclusion complexes, but now they are practically absent in literature. The purpose of this work is to fill in these gaps for γ-CD hydrates. γ–CD·nH2O hydrates with different water content (n = 4.95–15.93) have been synthesized and investigated by powder X-ray phase analysis (XRD), differential scanning calorimetry (DSC) and static method with glass membrane-gauge manometers. Static experiments were performed under condition of quasi-constant hydrate composition. The accuracy of measurements in static experiments was 0.5 Torr, 0.5 K and 0.01 formula units in the values of pressure, temperature and solid phase composition, accordingly [3]. As a result of the investigation, the thermal stability of the hydrates under study was established (DSC), their structures were clarified (XRD), and the temperature dependences of saturated water pressure in the dehydration processes were derived (static method). From the obtained data (p(T, n)), the enthalpies and entropies of the dehydration processes and the change in Gibbs energy during the binding of water by the CD framework were determined. The above thermodynamic information was used to estimate the binding energy of water molecules with γ–CD. Keywords • γ–cyclodextrin hydrates, dehydration, thermodynamic characteristics Acknowledgements The research was supported by the Russian Science Foundation (Grant No. 24-23-00237). References [1] G. Crini, Chem. Rev, 2014, 114, 10940-10975. [2] N. Sharma, A. Baldi, Drug Delivery, 2016, 23 (3), 729-747. [3] L. Zelenina, T. Chusova, A. Isakov, T. Rodionova, A. Manakov, S. Lyrshchikov, JCT, 201 (2025), 107401.

Библиографическая ссылка: Zelenina L. , Chusova T. , Rodionova T. , Manakov A. , Laventosa Y.
Thermal investigation of γ-cyclodextrin hydrates
17th Mediterranean Conference on Calorimetry and Thermal Analysis 09-11 Jul 2025