Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione

Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione Full article

Journal

Polyhedron
ISSN: 1873-3719 , E-ISSN: 0277-5387

Output data

Year: 2020, Volume: 178, Article number : 114325, Pages count : 7 DOI: 10.1016/j.poly.2019.114325

Authors

Eremina Julia A. ^1,2,3 , Lider Elizaveta V. ^1,2 , Sukhikh Taisiya S. ^1,2 , Eltsov Ilia V. ² , Kuratieva Natalia V. ^1,2 , Zakharov Boris A. ^2,4 , Sheludyakova Liliya A. ^1,2 , Klyushova Lyubov S. ^3,7 , Ermakova Ekaterina A. ^1,2 , Dotsenko Victor V. ^5,6

Affiliations

1	Nikolaev Institute of Inorganic Chemistry
2	Novosibirsk State University
3	Institute of Molecular Biology and Biophysics – Subdivision of FRC FTM
4	Boreskov Institute of Catalysis SB RAS
5	Kuban State University
6	North Caucasus Federal University, Department of Chemistry
7	Scientific Institute of Clinical and Experimental Lymphology - Branch of the ICG SB RAS

The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don’t exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM.

Eremina J.A. , Lider E.V. , Sukhikh T.S. , Eltsov I.V. , Kuratieva N.V. , Zakharov B.A. , Sheludyakova L.A. , Klyushova L.S. , Ermakova E.A. , Dotsenko V.V.
Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione
Polyhedron. 2020. V.178. 114325 :1-7. DOI: 10.1016/j.poly.2019.114325 WOS Scopus РИНЦ OpenAlex

Submitted:	Aug 21, 2019
Accepted:	Dec 19, 2019
Published online:	Dec 23, 2019

Web of science:	WOS:000523754500026
Scopus:	2-s2.0-85077316510
Elibrary:	43219777
OpenAlex:	W2998304945

DB	Citing
Web of science	13
Scopus	14
Elibrary	13
OpenAlex	14