SYNTHESIS, STRUCTURE, AND STUDY OF THE BIOLOGICAL ACTIVITY OF Co(II), Ni(II), AND Cu(II) COMPLEXES WITH AN ENAMINEDIONE DERIVATIVE

SYNTHESIS, STRUCTURE, AND STUDY OF THE BIOLOGICAL ACTIVITY OF Co(II), Ni(II), AND Cu(II) COMPLEXES WITH AN ENAMINEDIONE DERIVATIVE Full article

Journal

Journal of Structural Chemistry
ISSN: 1573-8779 , E-ISSN: 0022-4766

Output data

Year: 2021, Volume: 62, Pages: 309-320 Pages count : 12 DOI: 10.1134/S0022476621020165

Authors

Eremina Yu.A. ¹ , Ermakova E.A. ^1,3 , Sukhikh T.S. ¹ , Klyushova L.S. ² , El’tsov I.V. ³ , Samsonenko D.G. ¹ , Dotsenko V.V. ⁴ , Zubenko A.A. ⁵ , Fetisov L.N. ⁵ , Kononenko K.N. ⁵ , Lider E.V. ¹

Affiliations

1	Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences
2	Institute of Molecular Biology and Biophysics, Subdivision of FRC FTM
3	Novosibirsk State University
4	Kuban State University
5	North Caucasian Area Research Veterinary Institute, Federal Rostov Agrarian Scientific Center

[Cu(L)2] (1), [Co(L)2] (2), [Ni(L)2]·H2O (3) complexes where L is 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dionate are synthesized. Single crystals of complexes 1-3 are obtained. According to X-ray crystallographic data, in the Co and Ni complexes, a coordination polyhedron N2O4 is a distorted octahedron, and in the Cu complex, N2O2 is a distorted square. L is a tridentate ligand coordinated by oxygen atoms of carbonyl and methoxy groups as well as the nitrogen atom of the amide group. The cytotoxic properties of 2-{[(2-methoxyphenyl)amino]methylene}-5,5-dimethyl-cyclohexane-1,3-dione and respective complexes are studied on the Hep2 cell line (human laryngeal carcinoma). The compounds are shown to not exhibit cytotoxic properties in the studied concentration range (1-50 μM). Antibacterial, protistocidal, and fungistatic properties of HL, its structural analogue 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL1), and complexes on their base are also studied. The antibacterial activity of HL and [Co(L1)2(C2H5OH)2] against S. aureus, of HL1 and [Co(L)2] against E. coli is revealed within 25-30% of the activity of reference drugs (ciprofloxacin, furazolidone). The [Ni(L1)2(C2H5OH)2] complex is found to have a pronounced protistocidal activity. Furthermore, the behavior of the [Ni(L)2]·H2O complex in phosphate buffered saline is analyzed at storage times t = 0 h, 24 h, 48 h and also in an aqueous solution at different pH values.

Eremina Y.A. , Ermakova E.A. , Sukhikh T.S. , Klyushova L.S. , El’tsov I.V. , Samsonenko D.G. , Dotsenko V.V. , Zubenko A.A. , Fetisov L.N. , Kononenko K.N. , Lider E.V.
SYNTHESIS, STRUCTURE, AND STUDY OF THE BIOLOGICAL ACTIVITY OF Co(II), Ni(II), AND Cu(II) COMPLEXES WITH AN ENAMINEDIONE DERIVATIVE
Journal of Structural Chemistry. 2021. V.62. P.309-320. DOI: 10.1134/S0022476621020165 WOS Scopus РИНЦ OpenAlex

Еремина Ю.А. , Ермакова Е.А. , Сухих Т.С. , Клюшова Л.С. , Ельцов И.В. , Самсоненко Д.Г. , Доценко В.В. , Зубенко А.А. , Фетисов Л.Н. , Кононенко К.Н. , Лидер Е.В.
Синтез, строение и исследование биологической активности комплексов Co(II), Ni(II) и Cu(II) c производным енаминдиона
Журнал структурной химии. 2021. Т.62. №2. С.325-337. DOI: 10.26902/jsc_id68376 РИНЦ OpenAlex

Submitted:	Jul 28, 2020
Accepted:	Sep 3, 2020
Published print:	Mar 16, 2021

Web of science:	WOS:000629622600016
Scopus:	2-s2.0-85102718073
Elibrary:	46782989
OpenAlex:	W3136614203

DB	Citing
Web of science	6
Scopus	8
Elibrary	6
OpenAlex	9