Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells

Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells Full article

Journal

Inorganica Chimica Acta
ISSN: 1873-3255 , E-ISSN: 0020-1693

Output data

Year: 2022, Volume: 535, Article number : 120879, Pages count : 10 DOI: 10.1016/j.ica.2022.120879

Authors

Matveevskaya Vladislava V. ¹ , Pavlov Dmitry I. ¹ , Samsonenko Denis G. ¹ , Bonfili Laura ² , Cuccioloni Massimiliano ² , Benassi Enrico ³ , Pettinari Riccardo ⁴ , Potapov Andrei S. ¹

Affiliations

1	Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., Novosibirsk 630090, Russia
2	School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, Camerino, Macerata 62032, Italy
3	Novosibirsk State University, 2 Pirogov Str., Novosibirsk 630090, Russia
4	School of Pharmacy, Chemistry Section, University of Camerino, Via S. Agostino 1, Camerino, Macerata 62032, Italy

Six new arene-ruthenium(II) complexes containing two different η6-arene ligands – benzene and hexamethylbenzene, with indenoquinoxalinone oxime analogues (11H-indeno[1,2-b]quinoxalin-11-one oxime, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one oxime and 6–(hydroxyimino)indolo[2,1-b]quinazolin-12(6H)-one oxime (tryptanthrin-6-oxime)) as N,N’- chelating ligands are reported. The complexes were characterized by elemental analysis, IR, UV–VIS, 1H and 13C NMR spectroscopy and by single-crystal X-ray structure analysis. Complexes adopt a half-sandwich «piano-stool» geometry with oxime ligands in anionic form, the ruthenium(II) center coordinates one arene, one N,N-bidentate oximate and one chloride ligand. The computational analysis of non-covalent intermolecular interactions revealed weak attraction between the oxime oxygen atoms and the nearest hydrogen atoms of the oxime and the arene ligands. The cytotoxic activity of the complexes was evaluated against human breast cancer cell line MCF-7 and cisplatin-resistant human breast cancer cell line MCF-7CR as well as non-cancerous human breast epithelial cell line MCF10A. The cytotoxicity tests show micromolar IC50 values and tryptanthrin-6-oxime hexamethylbenzene-ruthenium(II) complex was found to exhibit the best antiproliferative activity among the studied compounds against the MCF-7 and MCF-7CR cell lines (IC50 9.0 ± 4.4 and 8.9 ± 1.5 µM, respectively).

Matveevskaya V.V. , Pavlov D.I. , Samsonenko D.G. , Bonfili L. , Cuccioloni M. , Benassi E. , Pettinari R. , Potapov A.S.
Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells
Inorganica Chimica Acta. 2022. V.535. 120879 :1-10. DOI: 10.1016/j.ica.2022.120879 WOS Scopus OpenAlex

Submitted:	Dec 27, 2021
Accepted:	Feb 18, 2022
Published online:	Feb 22, 2022
Published print:	Feb 24, 2022

Web of science:	WOS:000780254700001
Scopus:	2-s2.0-85125136122
OpenAlex:	W4212775794

DB	Citing
Web of science	10
Scopus	13
OpenAlex	13