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Ti-Containing Mesh Implants Modified by Heterostructures Based on Noble Metal: Fabrication and Study of Biological Activity Full article

Journal Journal of Functional Biomaterials
ISSN: 2079-4983
Output data Year: 2026, Volume: 17, Number: 11, Article number : 547, Pages count : 29 DOI: 10.3390/jfb17110547
Tags titanium-based mesh implants; heterostructures; Ag nanomaterials; chemical vapor deposition; antibacterial activity; cytotoxicity
Authors Dorovskikh Svetlana 1,2 , Vikulova Evgeniia 1,2 , Sergeevichev David 2 , Guselnikova Tatiana 1 , Kolodin Aleksey 1 , Fedorenko Anastasiya 1 , Zheravin Alexander 2 , Morozova Natalya 1,2
Affiliations
1 Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Ac. Lavrentiev Ave. 3, 630090 Novosibirsk, Russia
2 Meshalkin National Medical Research Center, Ministry of Public Health of the Russian Federation, Rechkunovskaya Str. 15, 630055 Novosibirsk, Russia

Funding (1)

1

Abstract: Ti-based mesh implants (“titanium silk” TiS and NiTi alloy) offer excellent tissue integration for oncologic surgery but lack intrinsic antibacterial activity. To address this, we fabricated Ag nanoparticles and Ag/M (M = Pt, Au) heterostructures on mesh surfaces via vapor-phase deposition, with noble metal sublayers functionalized by Ag nanofilms and nanoclusters. The modified implants were comprehensively characterized using SEM, AFM, XPS, and ICP-AES and evaluated through in vitro biocompatibility and antibacterial assays. The functional performance of the heterostructures is governed by two key phenomena: a chemical sublayer effect and a geometry-dependent substrate effect, which together dictate ion release kinetics. The Ag/Au interface sustains Ag+ release, whereas Ag/Pt drives rapid Ag+ dissolution. All heterostructures demonstrated effective antibacterial activity against planktonic S. aureus within 24 h. Key factors responsible for reduction in the more resilient P. aeruginosa on the Ag/M heterostructures were hypothesized. Cytotoxicity was dictated by the released ion cocktail: Ag/Pt/NiTi exhibited elevated toxicity which may be associated with the combined release of Ag+, Ni2+ and Pt2+, whereas all Ag/Au-based heterostructures showed excellent biocompatibility (viability 75–108%). Notably, gold sublayers were associated with elevated IL-10 secretion by 72 h. Based on overall biological performance, Ag/Au heterostructures offering sustained antibacterial activity against planktonic bacteria, low cytotoxicity, and a cytokine profile that may be favorable for long-term integration are promising candidates for mesh implants. Also, h-Ag/Pt/TiS showed an optimal balance between rapid antibacterial action and biocompatibility and therefore appears to be a suitable candidate for further in vivo investigation.
Cite: Dorovskikh S. , Vikulova E. , Sergeevichev D. , Guselnikova T. , Kolodin A. , Fedorenko A. , Zheravin A. , Morozova N.
Ti-Containing Mesh Implants Modified by Heterostructures Based on Noble Metal: Fabrication and Study of Biological Activity
Journal of Functional Biomaterials. 2026. V.17. N11. 547 :1-29. DOI: 10.3390/jfb17110547 OpenAlex
Dates:
Submitted: Sep 7, 2026
Accepted: Oct 23, 2026
Published print: Oct 27, 2026
Published online: Oct 27, 2026
Identifiers:
≡ OpenAlex: W7223813356
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