Reactions of polyfluorinated chalcones with hydroxylamine and subsequent intramolecular cyclization

Reactions of polyfluorinated chalcones with hydroxylamine and subsequent intramolecular cyclization Full article

Journal

Journal of Fluorine Chemistry
ISSN: 1873-3328 , E-ISSN: 0022-1139

Output data

Year: 2026, Volume: 292, Article number : 110591, Pages count : 8 DOI: 10.1016/j.jfluchem.2026.110591

Tags

Polyfluorinated chalcones Reactions with hydroxylamine Oximes Dihydroquinolines Benzisoxazole

Authors

Gavrilov I.N. ^1,2 , Orlova N.A. ¹ , Demakov P.A. ³ , Rybalova T.V. ¹

Affiliations

1	Vorozhtsov Novosibirsk Institute of Organic Chemistry, Russian Academy of Sciences, Siberian Branch, Acad. Lavrent′ev Prospect 9, Novosibirsk 630090, Russia
2	Novosibirsk National Research State University, Pirogov Street 1, Novosibirsk 630090, Russia
3	Nikolaev Institute of Inorganic Chemistry, Russian Academy of Sciences, Siberian Branch, Acad. Lavrent′ev Prospect 3, Novosibirsk 630090, Russia

Polyfluorinated chalcones react with hydroxylamine hydrochloride to form oximes, 3-hydroxylaminooximes, dihydroquinoline and benzisoxazole derivatives, depending on the chalcone structure and the reaction conditions. The last two structure types are formed as a result of intramolecular cyclization by replacing the ortho-fluorine atom in the perfluoro phenyl ring next to the carbonyl group.

Gavrilov I.N. , Orlova N.A. , Demakov P.A. , Rybalova T.V.
Reactions of polyfluorinated chalcones with hydroxylamine and subsequent intramolecular cyclization
Journal of Fluorine Chemistry. 2026. V.292. 110591 :1-8. DOI: 10.1016/j.jfluchem.2026.110591

Submitted:	May 15, 2026
Accepted:	Jun 15, 2026
Published online:	Jun 23, 2026
Published print:	Jul 1, 2026

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