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Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate Full article

Journal Journal of Dispersion Science and Technology
ISSN: 0193-2691 , E-ISSN: 1532-2351
Output data Year: 2021, Volume: 42, Number: 2, Pages: 173-179 Pages count : 7 DOI: 10.1080/01932691.2020.1711770
Tags Bismuth-potassium-ammonium citrate; freeze-drying; dynamic light scattering; nucleation
Authors Naydenko Ekaterina S. 1 , Podlipskaya Tatyana Yu. 2 , Yukhin Yurii M. 1 , Ogienko Andrey G. 2,3
Affiliations
1 Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia ;
2 Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia
3 Department of Natural Sciences, Novosibirsk State University , Novosibirsk , Russia

Abstract: The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.
Cite: Naydenko E.S. , Podlipskaya T.Y. , Yukhin Y.M. , Ogienko A.G.
Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate
Journal of Dispersion Science and Technology. 2021. V.42. N2. P.173-179. DOI: 10.1080/01932691.2020.1711770 WOS Scopus OpenAlex
Dates:
Submitted: Oct 11, 2018
Accepted: Aug 31, 2019
Published online: Jan 16, 2020
Identifiers:
≡ Web of science: WOS:000507449600001
≡ Scopus: 2-s2.0-85078619538
≡ OpenAlex: W3000357680
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