Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives

Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives Full article

Journal

Dalton Transactions
ISSN: 1477-9234 , E-ISSN: 1477-9226

Output data

Year: 2021, Volume: 50, Number: 38, Pages: 13516-13527 Pages count : 12 DOI: 10.1039/d1dt02190g

Authors

Yakovlev Ivan A. ¹ , Mikhailov Artem A. ¹ , Eremina Julia A. ¹ , Klyushova Lyubov S. ² , Nadolinny Vladimir A. ¹ , Kostin Gennadiy A. ¹

Affiliations

1	Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia
2	Institute of Molecular Biology and Biophysics – Subdivision of FRC FTM, 2/12 Timakova str., Novosibirsk, Russia

The synthetic approaches for the preparation of trans(NO,OH)-cis(NO2,NO2)-[RuNO(L)2(NO2)2OH], where L = ethyl nicotinate (I) and methyl nicotinate (II), are reported. The structures of the complexes are characterized by X-ray diffraction and analyzed by Hirshfeld surface analysis. Both compounds show a nitric oxide release reaction under 445 or 532 nm irradiation of dimethyl sulfoxide (DMSO) solutions, which is studied by combined ultraviolet-visible- (UV-vis), infrared- (IR), and electron paramagnetic resonance (EPR) spectroscopy and density functional theory (DFT) calculations. The charge transfer from the OH–Ru–NO chain and nitrite ligands to the antibonding orbitals of Ru–NO is responsible for the photo-cleavage of the ruthenium–nitrosyl bond. The elimination of NO leads to a side reaction, namely the protonation of the parent hydroxyl compound. The cytotoxicity and photo-induced cytotoxicity investigations of both compounds on the breast adenocarcinoma cell line MCF-7 reveal that (I) and (II) are cytotoxic with IC50 values of 27.5 ± 2.8 μM and 23.3 ± 0.3 μM, respectively. Moreover, (I) shows an increase of the toxicity after light irradiation by 7 times (IC50 = 4.1 ± 0.1), which makes it a prominent target for deeper biological investigations.

Yakovlev I.A. , Mikhailov A.A. , Eremina J.A. , Klyushova L.S. , Nadolinny V.A. , Kostin G.A.
Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives
Dalton Transactions. 2021. V.50. N38. P.13516-13527. DOI: 10.1039/d1dt02190g WOS Scopus РИНЦ OpenAlex

Submitted:	Jul 1, 2021
Accepted:	Aug 18, 2021
Published print:	Aug 18, 2021
Published online:	Aug 18, 2021

Web of science:	WOS:000703640600001
Scopus:	2-s2.0-85116656618
Elibrary:	47511471
OpenAlex:	W3193666477

DB	Citing
OpenAlex	11
Web of science	6
Scopus	9
Elibrary	10