DNA and gold(III) complexes with nitrogen-containing ligands Full article
| Journal |
Inorganica Chimica Acta
ISSN: 1873-3255 , E-ISSN: 0020-1693 |
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| Output data | Year: 2025, Volume: 580, Article number : 122591, Pages count : 8 DOI: 10.1016/j.ica.2025.122591 | ||
| Tags | Gold(I) complexes, Thiomalate, Glutathione, Cysteine, Redox processes | ||
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Abstract:
The interaction of four gold(III) complexes with N-containing polydentate ligands – Au (bipy)(OH)2+, Au(phen) (OH)2+, Au(C9H19N4)2+, Au(C14H22N4)+ and one gold(I) complex Au(GSH)23- – with salmon sperm DNA in an aqueous solution at 25 ◦C, pH 7.4, 0.1 M NaCl was studied. In the UV spectra of the complexes in the presence of DNA, no changes were observed compared to the spectra of solutions without DNA, indicating the absence of formation of new chemical bonds. In the fluorescence spectra of solutions containing DNA and ethidium bromide, a noticeable decrease in intensity was observed only for the macrocyclic unsaturated complex Au (C14H22N4)+. For other complexes, the changes were insignificant, i.e., they do not intercalate into DNA. It was also shown that the presence of DNA does not affect the redox interaction with glutathione of the studied gold (III) complexes.
Cite:
Mironov I.V.
, Kharlamova V.Y.
DNA and gold(III) complexes with nitrogen-containing ligands
Inorganica Chimica Acta. 2025. V.580. 122591 :1-8. DOI: 10.1016/j.ica.2025.122591 WOS OpenAlex
DNA and gold(III) complexes with nitrogen-containing ligands
Inorganica Chimica Acta. 2025. V.580. 122591 :1-8. DOI: 10.1016/j.ica.2025.122591 WOS OpenAlex
Dates:
| Submitted: | Oct 28, 2024 |
| Accepted: | Feb 9, 2025 |
| Published online: | Feb 11, 2025 |
| Published print: | May 24, 2025 |
Identifiers:
| Web of science: | WOS:001428858800001 |
| OpenAlex: | W4407381725 |
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