Sugar‐Decorated Dendritic Nanocarriers: Encapsulation and Release of the Octahedral Rhenium Cluster Complex [Re6S8(OH)6]4−

Sugar‐Decorated Dendritic Nanocarriers: Encapsulation and Release of the Octahedral Rhenium Cluster Complex [Re6S8(OH)6]4− Full article

Journal

Chemistry-an Asian Journal
ISSN: 1861-471X , E-ISSN: 1861-4728

Output data

Year: 2010, Volume: 5, Number: 12, Pages: 2507-2514 Pages count : 8 DOI: 10.1002/asia.201000284

Authors

Kubeil Manja ¹ , Stephan Holger ¹ , Pietzsch Hans‐Jürgen ¹ , Geipel Gerhard ² , Appelhans Dietmar ³ , Voit Brigitte ³ , Hoffmann Jan ⁴ , Brutschy Bernhard ⁴ , Mironov Yuri V. ⁵ , Brylev Konstantin A. ⁵ , Fedorov Vladimir E. ⁵

Affiliations

1	Forschungszentrum Dresden‐Rossendorf, Institute of Radiopharmacy
2	Forschungszentrum Dresden‐Rossendorf
3	Leibniz-Institute of Polymer Research Dresden
4	Johann‐Wolfgang‐Goethe Universität, Institute for Physical and Theoretical Chemistry
5	Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russia Academy of Sciences

The encapsulation of a nanometer-sized octahedral anionic rhenium cluster complex with six terminal hydroxo ligands [Re6S8(OH)(6)](4-) in maltose-decorated poly(propylene amine) dendrimers (POPAM, generation 4 and 5) has been investigated. Ultrafiltration experiments showed that maximal loading capacity of the dendrimers with the cluster complex is achieved after about ten hours in aqueous solution. To study the inclusion phenomena, three different methods have been applied: UV/Vis, time-resolved laser-induced fluorescence spectroscopy (TRLFS), and laser-induced liquid bead ion desorption mass spectrometry (LILBID-MS). From the results obtained, it could be concluded that: a) the hydrolytic stability of the rhenium cluster complex is significantly enhanced in the presence of dendritic hosts; b) the cluster anions are preferentially bound inside the dendrimers; c) the number of cluster complexes encapsulated in the dendrimers increases with rising dendrimer generation. On average, four to five cluster anions can preferentially be captured in the interior of sugar-coated dendritic carriers. An asymptotic progression of the release of cluster complexes from the loaded dendrimers was observed under physiologically relevant conditions (isotonic sodium chloride solution: approximately 93% within 4 days for loaded POPAM-G4-maltose; approximately 86% within 4 days for loaded POPAM-G5-maltose). These encapsulation and release properties of maltose-decorated nanocarriers imply the possibility for the development of the next generation of dendritic nanocarriers with specific targeting of destined tissue for therapeutic treatments.

Kubeil M. , Stephan H. , Pietzsch H. , Geipel G. , Appelhans D. , Voit B. , Hoffmann J. , Brutschy B. , Mironov Y.V. , Brylev K.A. , Fedorov V.E.
Sugar‐Decorated Dendritic Nanocarriers: Encapsulation and Release of the Octahedral Rhenium Cluster Complex [Re6S8(OH)6]4−
Chemistry-an Asian Journal. 2010. V.5. N12. P.2507-2514. DOI: 10.1002/asia.201000284 WOS OpenAlex

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