Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives

Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives Full article

Journal

Photochemical and Photobiological Sciences
ISSN: 1474-9092 , E-ISSN: 1474-905X

Output data

Year: 2024, Number: 23, Pages: 2265–2268 Pages count : DOI: 10.1007/s43630-024-00665-9

Tags

Adrenochrome, photolysis

Authors

Starodubtseva Ezhena S. ¹ , Karogodina Tatyana Yu. ¹ , Panfilov Mikhail A. ² , Sheven Dmitriy G. ³ , Selyutina Olga Yu. ⁴ , Vorob’ev Alexey Yu. ^1,2 , Moskalensky Alexander E. ¹

Affiliations

1	Novosibirsk State University, Novosibirsk, Russia
2	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, Russia
3	Nikolaev Institute of Inorganic Chemistry SB RAS, Novosibirsk, Russia
4	Voevodsky Institute of Chemical Kinetics and Combustion SB RAS, Novosibirsk, Russia

Control of biological activity with light is a fascinating idea. “Caged” compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. These receptors are largely used as pharmacologic targets. Photolabile “caged” analogs of adrenergic receptor agonists has been reported more than 30 years ago. We report that the photolysis of epinephrine analogs, apart from liberation of the epinephrine, is accompanied by a formation of significant amount of adrenochrome, a compound with neuro- and cardiotoxic effect.

Starodubtseva E.S. , Karogodina T.Y. , Panfilov M.A. , Sheven D.G. , Selyutina O.Y. , Vorob’ev A.Y. , Moskalensky A.E.
Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives
Photochemical and Photobiological Sciences. 2024. N23. P.2265–2268. DOI: 10.1007/s43630-024-00665-9 WOS Scopus РИНЦ OpenAlex

Submitted:	Jul 8, 2024
Accepted:	Nov 15, 2024
Published online:	Nov 15, 2024
Published print:	Dec 12, 2024

Web of science:	WOS:001366642400001
Scopus:	2-s2.0-85210550495
Elibrary:	79259758
OpenAlex:	W4404861917

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