Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives Full article
| Journal |
Photochemical and Photobiological Sciences
ISSN: 1474-9092 , E-ISSN: 1474-905X |
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| Output data | Year: 2024, Number: 23, Pages: 2265–2268 Pages count : DOI: 10.1007/s43630-024-00665-9 | ||||||||
| Tags | Adrenochrome, photolysis | ||||||||
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Abstract:
Control of biological activity with light is a fascinating idea. “Caged” compounds, molecules modified with photolabile protecting group, are one of the instruments for this purpose. Adrenergic receptors are essential regulators of neuronal, endocrine, cardiovascular, vegetative, and metabolic functions. These receptors are largely used as pharmacologic targets. Photolabile “caged” analogs of adrenergic receptor agonists has been reported more than 30 years ago. We report that the photolysis of epinephrine analogs, apart from liberation of the epinephrine, is accompanied by a formation of significant amount of adrenochrome, a compound with neuro- and cardiotoxic effect.
Cite:
Starodubtseva E.S.
, Karogodina T.Y.
, Panfilov M.A.
, Sheven D.G.
, Selyutina O.Y.
, Vorob’ev A.Y.
, Moskalensky A.E.
Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives
Photochemical and Photobiological Sciences. 2024. N23. P.2265–2268. DOI: 10.1007/s43630-024-00665-9 WOS Scopus РИНЦ OpenAlex
Adrenochrome formation during photochemical decomposition of “caged” epinephrine derivatives
Photochemical and Photobiological Sciences. 2024. N23. P.2265–2268. DOI: 10.1007/s43630-024-00665-9 WOS Scopus РИНЦ OpenAlex
Dates:
| Submitted: | Jul 8, 2024 |
| Accepted: | Nov 15, 2024 |
| Published online: | Nov 15, 2024 |
| Published print: | Dec 12, 2024 |
Identifiers:
| Web of science: | WOS:001366642400001 |
| Scopus: | 2-s2.0-85210550495 |
| Elibrary: | 79259758 |
| OpenAlex: | W4404861917 |