Spin crossover in new iron(II) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine

Spin crossover in new iron(II) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2024, Volume: 73, Number: 11, Pages: 3304-3317 Pages count : 14

Tags

synthesis, complexes, iron(II), 2,6-bis(1H-imidazol-2-yl)-4- methoxypyridine, spectroscopy, spin crossover, thermochromism, cytostatic effect.

Authors

Shakirova O.G. ^1,2 , Oskina I.A. ³ , Korotaev E.V. ¹ , Petrov C.A. ⁴ , Kozlova S.G. ¹ , Klyushova L.S. ⁵ , Tikhonov A.Ya. ³ , Lavrenova L.G. ¹

Affiliations

1	A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences
2	Komsomolsk-na-Amure State University
3	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
4	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences
5	Institute of Molecular Biology and Biophysics,Federal Research Center of Fundamental and Translational Medicine

New iron(II) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine (L), viz., [FeL2]Cl2•2H2O (1•2H2O), [FeL2](NO3)2•H2O (2•H2O), [FeL2](ClO4)2•0.5H2O (3•0.5H2O), and [FeL2]I2•C3H6O (4•C3H6O) were synthesized and studied. Conclusions about the structure of the compounds are based on the diffuse reflectance, IR, and Mössbauer spectroscopy data and on the results of static magnetic susceptibility measurements and quantum chemical calculations. The temperature dependences of the effective magnetic moments of the compounds synthesized, except 1·2H2O and 1, demonstrated features associated with spin crossover accompanied by thermochromism (changes of the color from orange to red-violet). The cytotoxic and cytostatic activity studies of the compounds in question revealed a cytostatic effect on the human hepatocellular carcinoma HepG2 cells characterized by 50% inhibitory concentration (IC50) values from 44.7 ± 0.4 to 58.8 ± 0.6 μmol L–1.

Shakirova O.G. , Oskina I.A. , Korotaev E.V. , Petrov C.A. , Kozlova S.G. , Klyushova L.S. , Tikhonov A.Y. , Lavrenova L.G.
Spin crossover in new iron(II) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine
Russian Chemical Bulletin. 2024. V.73. N11. P.3304-3317.

Шакирова О.Г. , Оськина И.А. , Коротаев Е.В. , Петров С.А. , Козлова С.Г. , Клюшова Л.С. , Тихонов А.Я. , Лавренова Л.Г.
Спин-кроссовер в новых комплексах железа(II) с 2,6-бис(1Н-имидазол-2-ил)-4-метоксипиридином
Известия Академии наук. Серия химическая. 2024. Т.73. №11. С.3304-3317.

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