6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one

6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2024, Volume: 2024, Number: 4, Article number : M1922, Pages count : 8 DOI: 10.3390/M1922

Authors

Kovrizhina Anastasia R. ¹ , Tolegen Dauren ¹ , Pavlov Dmitry I. ² , Potapov Andrei S. ² , Khlebnikov Andrei I. ¹

Affiliations

1	Kizhner Research Center, Tomsk Polytechnic University
2	Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences

We report the synthesis of the new compound 6,8-dibromo-11H-indeno[1,2-b]quinolin-11-one (Compound 3), which present an important type of nitrogen-containing heterocycles and is a useful intermediate product in organic synthesis. The compound was evaluated for potential biological activity and is promising for pharmaceutical applications. The structure of the compound was confirmed by the single crystal X-ray diffraction. Bioavailability was evaluated in silico using ADME predictions. The molecular docking results show that Compound 3 is a potential DNA intercalator. In summary, the synthesized indenoquinoline derivative 3 has prospectives to be used as the main component for the development of anti-cancer and anti-inflammatory drugs.

Kovrizhina A.R. , Tolegen D. , Pavlov D.I. , Potapov A.S. , Khlebnikov A.I.
6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one
Molbank. 2024. V.2024. N4. M1922 :1-8. DOI: 10.3390/M1922 WOS Scopus OpenAlex

Submitted:	Oct 26, 2024
Accepted:	Nov 19, 2024
Published print:	Nov 21, 2024
Published online:	Nov 21, 2024

Web of science:	WOS:001385656700001
Scopus:	2-s2.0-85213494037
OpenAlex:	W4404592946

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