Abstract: The temperature sensitivity of paramagnetic chemical shifts in 1H NMR spectra for the [Co(dtpa)]3- complex in 10% gelatin gel (as a model substrate of human or animal tissues) was studied in detail. The maximum temperature sensitivity of the chemical shifts d(δexp)/dT studied in the gelatin gel of the complex was found to be 0.73 ppm/K (which is about 7% higher than in the previously studied D2O solution of the compound). It turned out that the studied complex is characterized by the highest temperature sensitivity of chemical shifts in the NMR spectra among the complexes of paramagnetic d-elements. Moreover, this complex also shows the highest temperature sensitivity of chemical shifts taking into consideration the half-width of the signal itself (|CT|/W= 0.8 K-1). The [Co(dtpa)]3- complex can be considered as a promising compound for the design of temperature-sensitive NMR probes aimed at determining the local temperature in aqueous media and prospective MRI-assisted disease diagnosis.

Cite: Babailov S.P.
[Co(DTPA)]3− complex in gelatin gel as a highly sensitive shifting NMR/MRI temperature probe
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2022. V.102. N7-8. P.705-710. DOI: 10.1007/s10847-022-01151-4 WOS Scopus РИНЦ OpenAlex

Dates:

Submitted:	Jan 27, 2022
Accepted:	May 30, 2022
Published print:	May 30, 2022
Published online:	May 30, 2022

Identifiers:

Web of science:	WOS:000811410700001
Scopus:	2-s2.0-85132198658
Elibrary:	48723757
OpenAlex:	W4282977729

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