Photoaquation of cis-[Rh(dppz)(phen)Cl2]Cl complex prospective as potential light-activated anti-cancer agent

Photoaquation of cis-[Rh(dppz)(phen)Cl2]Cl complex prospective as potential light-activated anti-cancer agent Full article

Journal

Journal of Photochemistry and Photobiology A-chemistry
ISSN: 1010-6030 , E-ISSN: 1873-2666

Output data

Year: 2024, Volume: 452, Pages: 115621 Pages count : 1 DOI: 10.1016/j.jphotochem.2024.115621

Authors

Malakhova Iuliia ¹ , Polyakova Evgenia ² , Vasilchenko Danila ² , Grivin Vjacheslav ¹ , Pozdnyakov Ivan ¹ , Kokorenko Andrei ³ , Melnikov Alexei ⁴ , Chekalin Sergei ⁴ , Glebov Evgeni ^1,3

Affiliations

1	Voevodsky Institute of Chemical Kinetics and Combustion Siberian Branch of the Russian Academy of Sciences
2	Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences
3	Novosibirsk State University
4	Institute of Spectroscopy RAS

The photoactivated drug usage in anti-cancer therapy, the working mechanism of which doesn’t rely on the formation of reactive oxygen species, allows reducing damage to healthy tissue by controlling toxicity. For instance, light-activated Rh(III) complexes show nuclease activity after irradiation with UV and visible light. However, literature analysis shows a lack of descriptions of basic photochemical mechanisms. Here we report the study of cis-[Rh(dppz)(phen)Cl2]Cl (DPPZPHEN, dppz is dipyrido[3,2-a:2′,3′-c]phenazine, phen is 1,10-phenanthroline) photochemistry in water solutions using stationary photolysis, nanosecond laser flash photolysis and ultrafast pump–probe spectroscopy. After the irradiation with 308 nm light, DPPZPHEN undergoes aquation, which results in the substitution of one chloride ligand by a water molecule and leads to the formation of [Rh(dppz)(phen)(H2O)Cl]Cl2. UV–vis spectra of complex and capillary electrophoresis data were collected and discussed. Laser flash photolysis (355 nm) demonstrates intermediate absorption attributed to the lowest electronic excited state (triplet) of the initial complex. The study of primary photophysical processes showed a rather complicated behavior of transient absorption, which could be described by a set of four exponential functions. The early photophysical processes were described by the scheme including the formation of two excited states of different natures, namely a dppz-based IL state and an LMCT state.

Malakhova I. , Polyakova E. , Vasilchenko D. , Grivin V. , Pozdnyakov I. , Kokorenko A. , Melnikov A. , Chekalin S. , Glebov E.
Photoaquation of cis-[Rh(dppz)(phen)Cl2]Cl complex prospective as potential light-activated anti-cancer agent
Journal of Photochemistry and Photobiology A-chemistry. 2024. V.452. P.115621. DOI: 10.1016/j.jphotochem.2024.115621 WOS Scopus РИНЦ OpenAlex

Published print:	Mar 26, 2024
Published online:	Mar 26, 2024

Web of science:	WOS:001222838700001
Scopus:	2-s2.0-85188740720
Elibrary:	67298081
OpenAlex:	W4393182004

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