Abstract: Gold(III) complexes are widely stud- ied as antitumor agents and show good results. The interaction with biologically active thiols (thiomalate, cysteine, glutathione (GSH) and human serum albu- min) of a number of gold(III) complexes with N-con- taining polydentate ligands in aqueous solution with pH 7.4 and 0.2 M NaCl was studied. Complexes with 1,10-phenanthroline and 2,2′-bipyridyl, Au(phen) (OH) 2 + and Au(bipy)(OH) 2 + , react fast with an excess of any of these thiols and in less than a few seconds transform into gold(I) bis-thiolate complexes. For complexes with deprotonated ethylenediamine and diethylenetriamine, Au(en)(en-H) 2+ and Au(dien-H) (Cl,OH) + , at a significant excess of GSH, a relatively long-lived gold(III) complex Au III (GSH) i L j is formed. At t = 37 °C, it transforms into the gold(I) bis-thiolate complex Au(GSH) 2 by 90% in 4 h. However, for other thiols, the rate of decomposition of similar complexes is about 10 times higher. Some other complexes were also considered. In all cases, a fairly fast reduction of gold(III) to gold(I) occurs with the formation of the gold(I) bis-thiolates.

Cite: Mironov I.V. , Kharlamova V. , Makotchenko E.
Some remarks on the biological application of gold(III) complexes
Biometals. 2024. V.37. N1. P.233–246. DOI: 10.1007/s10534-023-00545-2 WOS Scopus РИНЦ OpenAlex

Dates:

Submitted:	Jul 24, 2023
Accepted:	Sep 23, 2023
Published online:	Oct 19, 2023

Identifiers:

Web of science:	WOS:001087425000001
Scopus:	2-s2.0-85174533456
Elibrary:	65201589
OpenAlex:	W4387764721

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